Performance MHI

While each of these growth hormone secretagogues operate through unique mechanisms and serve distinct functions, their collective aim is to optimize the body’s efficiency in the areas of: Energy, Stamina, Strength, Muscle Growth, Fat Burning, Exercise Recovery, Improved Sleep Quality, Joint & Tissue Health, Skin Elasticity, Immune function, Wound Healing, Lipid Stabilization, Anti-Aging Effects

Before you proceed, let us clarify a few key terms related to these specific types of peptides. Put simply, the primary role of these peptides is to stimulate the secretion of growth hormone.These growth hormone secretagogues fall into two categories.

What is a GHRH (Growth Hormone-Releasing Hormone)

​A GHRH triggers the hypothalamus and pituitary gland to release more growth hormone from the brain to the liver.

What is a GHRP (Growth Hormone-Releasing Peptide)

A GHRP triggers the liver to release growth hormone into the bloodstream.

To help illustrate the distinction, think of growth hormone as the fuel powering a race car. A GHRH acts like a pit crew member refilling the car with more fuel while a GHRP acts as a skilled pilot engaging a turbocharger to boost the car’s performance as needed.

NOTE: Because GHRHs “fill the tank” and GHRPs “empty the tank” they are exceptionally complimentary, and can be used in combination for greater results.

While each of these growth hormone secretagogues operate through unique mechanisms and serve distinct functions, their collective aim is to optimize the body's efficiency in the areas of:

• Energy/Stamina/Strength

• Muscle Growth

• Fat Burning

• Exercise Recovery

• Improved Sleep Quality

• Joint & Tissue Health

• Skin Elasticity

• Immune function

• Wound Healing

• Lipid Stabilization

• "Anti-Aging" Effects

Tesamorelin (GHRH)

44 amino acids & has a 5-6 hour half-life

This GHRH has shown to increase IGF-1 levels in men and women by an average of 181 micrograms/liter. This is by far the strongest & most effective peptide at increasing IGF-1 levels. Its potency makes it an ideal option for individuals seeking enhanced muscle growth, recovery, and overall vitality.

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Ipamorelin (GHRP)

5 amino acids & has a 2 hour half-life

Unlike other growth hormone-secretagogues, this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin, and aldosterone as other peptides can. For this reason it has been considered the first & best selective growth hormone-secretagogue.

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CJC-1295 (GHRH)

29 amino acids & has a 10-20 minute half-life

This is a tetrasubstituted peptide shown to increase growth hormone in enormous amounts. CJC 1295 will keep a steady increase of HGH and IGF-1 with no increase in prolactin. Its long half-life allows for less frequent dosing while maintaining consistent anabolic and metabolic benefits.

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Sermorelin (GHRH)

29 amino acids & has a 10-20 minute half-life

This ia “first generation” growth hormone secretagogue peptide. Although effective, it has shown to increase more prolactin and cortisol than other GHRH/GHRP peptides. Due to these side effects, its use is typically limited or combined with other peptides to balance the hormonal response.

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Hexarelin (GHRP)

6 amino acids & has a 55 minute half-life

Hexarelin, a growth hormone secretagogue, has been studied for its medical benefits. It stimulates growth hormone release from the pituitary gland, leading to increased muscle mass, strength, and faster injury recovery. It also supports fat loss by enhancing lipid metabolism and body composition. Additionally, hexarelin may protect heart tissue, lower blood pressure, and improve cardiac function. Some studies suggest it also boosts bone density and aids tissue healing.

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IGF-1 LR (Polypeptide)

83 amino acids & has a 20-30 hour half-life

A polypeptide is a long chain of amino acids, usually over 50 in length. IGF-1 LR3 is a modified form of insulin-like growth factor 1 with a longer half-life than natural IGF-1. It activates both MAP kinase and PI3K pathways, acting in nearly all body tissues. Commonly used to promote muscle growth, IGF-1 LR3 also increases insulin sensitivity, helping mobilize fat for energy. In lean tissue, it blocks insulin from moving glucose into cells, forcing them to burn fat as an energy source.

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SS-31

2 amino acids & 3 hour half-life

SS-31 or Elamipretide offers benefits for mitochondrial health. It binds to cardiolipin in the inner mitochondrial membrane, enhancing function and reducing reactive oxygen species, oxidative stress, and cellular damage. This boosts energy production and supports conditions like heart disease, neurodegeneration, and age-related muscle loss. It also helps protect against sudden blood flow loss, such as in heart attacks and strokes.

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MK-677 (Ibutamoren)

Has a 24 hour half-life

Is neither a peptide nor a SARM (selective androgen receptor modulator). It is actually classified as a growth hormone secretagogue. It works by stimulating the release of growth hormone and increasing levels of insulin-like growth factor 1 (IGF-1) in the body. It’s an oral compoundI that stimulates the release of growth hormone by binding to the ghrelin (28 amino acids) receptors. It’s main target in our biochemistry is to increase muscle growth.

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OS-01 (ATX-304) – oral form

Small molecule therapeutic & unknown half-life

OS-01 is a direct pan-AMPK activator, meaning it stimulates all forms of AMPK—the master switch for cellular energy. As we age, AMPK activity declines, slowing metabolism, fat burning, and cellular repair. OS-01 restores this function by preventing deactivation of AMPK and acting as a mild mitochondrial uncoupler, which boosts energy output. This dual action helps improve glucose control, enhance fat metabolism, support cardiovascular performance, reduce inflammation, and protect kidneys and other organs.

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